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When an old friend and former patient of Wilson's experiences paralysis in his right arm, Wilson puts himself on the case. House wagers Wilson that the patient's symptoms result from new cancer cells. Wilson accepts even though he is reluctant to believe the cancer has returned. With the help of the team, Wilson works to find a more optimistic diagnosis, but when things take a turn for the worse, and Wilson must address his inability to separate patient from friend. Meanwhile, Cuddy seeks advice in her search for real estate.